Hydrophobically modified alginate for extended release of pharmaceuticals

A hydrophobically-modified alginate gel system: utility in the repair of articular cartilage defects.

Alginate is a family of natural polysaccharides, widely used in industry and medicine for many applications, with its non toxic nature, gentle sol/gel transition procedure and low cost, alginate inferior biomechanical properties have limited its utility especially in tissue engineering. Additionally, ionically cross-linked alginate hydrogels generally lose most of their initial mechanical and s...

Surfactants modify the release from tablets made of hydrophobically modified poly (acrylic acid)☆

Many novel pharmaceutically active substances are characterized by a high hydrophobicity and a low water solubility, which present challenges for their delivery as drugs. Tablets made from cross-linked hydrophobically modified poly (acrylic acid) (CLHMPAA), commercially available as Pemulen™, have previously shown promising abilities to control the release of hydrophobic model substances. This ...

Release of a Poorly Soluble Drug from Hydrophobically Modified Poly (Acrylic Acid) in Simulated Intestinal Fluids

A large part of new pharmaceutical substances are characterized by a poor solubility and high hydrophobicity, which might lead to a difference in drug adsorption between fasted and fed patients. We have previously evaluated the release of hydrophobic drugs from tablets based on Pemulen TR2 and showed that the release can be manipulated by adding surfactants. Here we further evaluate the possibi...

Hydrophobically Modified Chitosan Gauze for Control of Massive Hemorrhage

Hydrophobically Modified Hydroxypropyl Methylcellulose in Rats

A six-month repeated-dose dermal toxicity study fo11owed by a 30-day recovery test of hydrophobically modified hydroxypropyl methylcellulose (HM-HPMC), a new ceLlulose derivative used as a thickener for topical pharmaceuticals, was conducted using rats, Aqueous paste of HM-HPMC was applied to the skin ofrats once daily at dose levels up to 60 mg/kglday, which was the highest dose that could be ...